1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

It is well-established that the nutritional deficiency or inadequacy can impair immune
functions. Growing evidence suggests that for certain nutrients increased intake above …

Inappropriate activation of the renin-angiotensin system, which plays a central role in the
regulation of blood pressure, electrolyte, and volume homeostasis, may represent a major …

Regulation of immune function continues to be one of the most well recognized extraskeletal
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …

▪ Abstract As targets for the immunosuppressive drugs cyclosporin A and FK506,
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the …

The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1, 25 …

Vitamins are essential constituents of our diet that have long been known to influence the
immune system. Vitamins A and D have received particular attention in recent years as …

Abstract Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current
Understanding of the Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193–1231, 1998 …

IN THE DECADE SINCE THE VITAMIN Dreceptor (VDR) was cloned (1) and recognized as
a member of the superfamily of nuclear receptors that regulate gene expression in a ligand …

Abstract 1α, 25-Dihydroxyvitamin D3 (vitD3) is an immunoregulatory hormone with
beneficial effects on Th1 mediated autoimmune diseases. Although the inhibitory effects of …