Coeliac disease: dissecting a complex inflammatory disorder
LM Sollid - Nature Reviews Immunology, 2002 - nature.com
The disease mechanisms of complex inflammatory disorders are difficult to define because
of extensive interactions between genetic and environmental factors. Coeliac disease is a …
of extensive interactions between genetic and environmental factors. Coeliac disease is a …
Molecular basis of celiac disease
LM Sollid - Annual review of immunology, 2000 - annualreviews.org
Celiac disease (CD) is an intestinal disorder with multifactorial etiology. HLA and non-HLA
genes together with gluten and possibly additional environmental factors are involved in …
genes together with gluten and possibly additional environmental factors are involved in …
Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
Background The adaptive immune system is central to the development of coeliac disease.
Adaptive immune responses are, however, controlled by a preceding activation of the innate …
Adaptive immune responses are, however, controlled by a preceding activation of the innate …
Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease
Background & Aims: Celiac disease appears to be a T cell–mediated enteropathy induced
by gluten in genetically predisposed individuals. Duodenal biopsy specimens from patients …
by gluten in genetically predisposed individuals. Duodenal biopsy specimens from patients …
Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma.
Coeliac disease is precipitated in susceptible subjects by ingestion of wheat gluten or gluten
related prolamins from some other cereals. The disease is strongly associated with certain …
related prolamins from some other cereals. The disease is strongly associated with certain …
Interleukin 15 mediates epithelial changes in celiac disease
Background & Aims: Villous atrophy and crypt proliferation are key epithelial features of
untreated celiac disease. We tried to define whether cytokines such as interleukin (IL)-15, IL …
untreated celiac disease. We tried to define whether cytokines such as interleukin (IL)-15, IL …
The gluten connection: the association between schizophrenia and celiac disease
AE Kalaydjian, W Eaton, N Cascella… - Acta Psychiatrica …, 2006 - Wiley Online Library
Objective: Schizophrenia affects roughly 1% of the population and is considered one of the
top 10 causes of disability worldwide. Given the immense cost to society, successful …
top 10 causes of disability worldwide. Given the immense cost to society, successful …
Gliadin specific, HLA DQ2‐restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls
The authors have analysed gliadin specific, CD4+ T cells isolated from small intestinal
biopsies of 23 adult coeliac disease patients (20 on a gluten‐free diet and three untreated) …
biopsies of 23 adult coeliac disease patients (20 on a gluten‐free diet and three untreated) …
T cells from the small intestinal Mucosa of a DR4, DQ7/DR4. DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
CD is an immunologic disease of the small intestine which is precipitated by ingestion of
wheat gliadin. Most patients carry the HLA-DQ (α1∗ 0501, β1∗ 0201)(DQ2) heterodimer …
wheat gliadin. Most patients carry the HLA-DQ (α1∗ 0501, β1∗ 0201)(DQ2) heterodimer …
Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease
Background: Coeliac disease (CD) is caused by a T helper cell type 1 (Th1) response in the
small intestinal mucosa to dietary gluten. Paradoxically, interleukin (IL)-12, the major Th1 …
small intestinal mucosa to dietary gluten. Paradoxically, interleukin (IL)-12, the major Th1 …