Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …

Abstract Iron–sulfur (Fe–S) clusters are versatile protein cofactors that require numerous
components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of …

MUTYH is a base excision repair enzyme, it plays a crucial role in the correction of DNA
errors from guanine oxidation and may be considered a cell protective factor. In humans it is …

Reactive oxygen and nitrogen species (RONS) may infringe on the passing of pristine
genetic information by inducing DNA inter-and intra-strand crosslinks, protein-DNA …

Abstract The Base Excision Repair (BER) pathway is a highly conserved DNA repair system
targeting subtle chemical base modifications that arise from oxidation, deamination and …

The stacked aromatic base pairs within the DNA double helix facilitate charge transport
down its length in the absence of lesions, mismatches, and other stacking perturbations …

MUTYH is a base-excision repair glycosylase that removes adenine opposite 8-oxoguanine
(OG). Variants of MUTYH defective in functional activity lead to MUTYH-associated …

Mammalian MutY homologue (MUTYH) is an adenine DNA glycosylase that excises
adenine inserted opposite 8-oxoguanine (8-oxoG). The inherited variations in human …

MUTYH is a base excision repair (BER) enzyme that prevents mutations in DNA associated
with 8-oxoguanine (OG) by catalyzing the removal of adenine from inappropriately formed …

Background: Germline mutations provide the raw material for all evolutionary processes and
contribute to the occurrence of spontaneous human diseases and disorders. Yet despite the …