Atherogenesis, the formation of atherosclerotic plaques, is a complex process that involves
several mechanisms, including endothelial dysfunction, neovascularization, vascular …

Hydroxyl radical (radical dot OH) and one-electron oxidants that may be endogenously
formed through oxidative metabolism, phagocytosis, inflammation and pathological …

The comet assay or single cell gel electrophoresis, is the most common method used to
measure strand breaks and a variety of other DNA lesions in human populations. To …

DNA damage response (DDR) signaling ensures genomic and proteomic homeostasis to
maintain a healthy genome. Dysregulation either in the form of down‐or upregulation in the …

Recent investigations have revealed that changes in DNA methylation status play an
important role in aging-associated pathologies and lifespan. The methylation of DNA is …

Because bisphenol A (BPA) and some of its analogs have been supposed to influence
development of cancer, we have assessed the effect of BPA, bisphenol S (BPS), bisphenol F …

Vascular aging plays a central role in health problems and mortality in older people. Apart
from the impact of several classical cardiovascular risk factors on the vasculature …

The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney
disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases …

The human genome is persistently exposed to damage caused by xenobiotics, therefore the
assessment of genotoxicity of substances having a direct contact with humans is of …

Recent data support the involvement of epigenetic alterations in the pathogenesis of
atherosclerosis. The most widely investigated epigenetic mechanism is DNA methylation …