Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility

LC Carneiro, JG Cronin, IM Sheldon - Reproductive biology, 2016 - Elsevier
Bacterial infections of the endometrium after parturition commonly cause metritis and
endometritis in dairy cattle, and these diseases are important because they compromise …

Innate immunity and inflammation of the bovine female reproductive tract in health and disease

IM Sheldon, JG Cronin, GD Healey, C Gabler… - …, 2014 - rep.bioscientifica.com
In mammals, the sperm activates the development of the egg by triggering a series of
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …

Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like …

ML Turner, JG Cronin, GD Healey, IM Sheldon - Endocrinology, 2014 - academic.oup.com
Bacteria often infect the endometrium of cattle to cause endometritis, uterine disease, and
infertility. Lipopeptides are commonly found among bacteria and are detected by the Toll …

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow,

JJ Bromfield, JEP Santos, J Block… - Journal of animal …, 2015 - academic.oup.com
Uterine contamination with bacteria is ubiquitous in the postpartum dairy cow. Nearly one-
half of all postpartum dairy cows develop clinical disease resulting in metritis and …

Differential Endometrial Cell Sensitivity to a Cholesterol-Dependent Cytolysin Links Trueperella pyogenes to Uterine Disease in Cattle

MR Amos, GD Healey, RJ Goldstone… - Biology of …, 2014 - academic.oup.com
Purulent disease of the uterus develops in 40% of dairy cows after parturition, when the
epithelium of the endometrium is disrupted to expose the underlying stroma to bacteria. The …

Lipopolysaccharide reduces the primordial follicle pool in the bovine ovarian cortex ex vivo and in the murine ovary in vivo

JJ Bromfield, IM Sheldon - Biology of reproduction, 2013 - academic.oup.com
Infections of the uterus or mammary gland with Gram-negative bacteria cause infertility in
cattle, not only during disease but also for some time afterward. Even though these …

Interferon tau-dependent and independent effects of the bovine conceptus on the endometrial transcriptome

DJ Mathew, JM Sánchez, C Passaro… - Biology of …, 2019 - academic.oup.com
This study investigated bovine conceptus-induced modifications to the endometrial
transcriptome related to effects of interferon tau (IFNT), conceptus origin (in vivo vs. in vitro) …

Immunity and inflammation in the uterus

ML Turner, GD Healey… - Reproduction in Domestic …, 2012 - Wiley Online Library
Contents Microbes often infect the uterus and particularly the endometrium of animals.
Infections are most commonly associated with natural service, pregnancy and the post …

Pathogen-associated molecular patterns initiate inflammation and perturb the endocrine function of bovine granulosa cells from ovarian dominant follicles via TLR2 …

JC Price, JJ Bromfield, IM Sheldon - Endocrinology, 2013 - academic.oup.com
Bacterial infections of the uterus or mammary gland commonly cause disease and infertility
by perturbing growth and steroidogenesis of the dominant follicle in the ovary of cattle. Cells …

Progesterone inhibits inflammatory response in E. coli-or LPS-Stimulated bovine endometrial epithelial cells by NF-κB and MAPK pathways

L Cui, H Wang, J Lin, Y Wang, J Dong, J Li… - Developmental & …, 2020 - Elsevier
Progesterone suppresses the innate immune function of bovine endometrium, making the
uterus susceptible to bacterial infection. The bovine endometrial epithelial cells (BEEC) are …