Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …

Oxidative stress is proposed as a regulatory element in ageing and various neurological
disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce …

Ferroptosis is a regulated necrosis process driven by iron-dependent lipid peroxidation.
Although ferroptosis and cellular metabolism interplay with one another, whether …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Free radicals are common outcome of normal aerobic cellular metabolism. In-built
antioxidant system of body plays its decisive role in prevention of any loss due to free …

Microwave ablation (MWA) as a local tumor ablation strategy suffers from posttreatment
tumor recurrence. Development of adjuvant biomaterials to potentiate MWA is therefore of …

To investigate whether the tumor suppressor gene PTEN affects the activity of the androgen
receptor (AR), we monitored the expression of the apoptotic gene HA-Bax (inserted in an …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Multiple death signals influence mitochondria during apoptosis, yet the critical initiating
event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated …

New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …