Highlights•Cell–cell fusion is a tractable system for studying the earliest events in lineage
reprogramming.•There is untapped potential to combine cell–cell fusion and single cell …

Protein arginine methylation is a posttranslational modification catalyzed by protein arginine
methyltransferases (PRMTs), which play critical roles in many biological processes. To date …

Embryonic stem cells (ESCs) can instruct the conversion of differentiated cells toward
pluripotency following cell-to-cell fusion by a mechanism that is rapid but poorly understood …

Direct lineage conversion is a promising approach for disease modeling and regenerative
medicine. Cell divisions play a key role in reprogramming of somatic cells to pluripotency …

Patient-specific induced pluripotent stem cells (iPSCs) have the potential to be useful in the
treatment of human diseases. While prior studies have reported multiple methods to …

The foundations of cell reprogramming were laid by Yamanaka and co-workers, who
showed that somatic cells can be reprogrammed into pluripotent cells (induced …

For the first time, two types of hybrid cells with embryonic stem (ES) cell-like and fibroblast-
like phenotypes were produced through the fusion of mouse ES cells with fibroblasts …

Fusion of somatic cells to embryonic stem cells induces reprogramming of the somatic
nucleus and can be used to study the effect of trans-acting factors from the pluripotent cell …

Cell-to-cell fusion can be quantified by endowing acceptor and donor cells with latent
reporter genes/proteins and activators of these genes/proteins, respectively. One way to …

Cell reprogramming has recently emerged as a promising method for tissue regeneration,
originating from Gurdon and colleagues' groundbreaking research that showed that somatic …