Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and play
essential roles in tissue regeneration and homeostasis. MSCs can be isolated from …

BMP signaling plays an important role in dentin development. BMPs and antagonists
regulate odontoblast differentiation and downstream gene expression via canonical Smad …

Cranial neural crest cells are an evolutionary innovation of vertebrates for craniofacial
development and function, yet the mechanisms that govern the cell fate decisions of …

Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem
cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as …

The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Sonic hedgehog (Shh) is a secreted protein with important roles in mammalian
embryogenesis. During tooth development, Shh is primarily expressed in the dental …

Jaw bones and teeth originate from the first pharyngeal arch and develop in closely related
ways. Reciprocal epithelial-mesenchymal interactions are required for the early patterning …

Progenitor cells are crucial in controlling organ morphogenesis. Tooth development is a well‐
established model for investigating the molecular and cellular mechanisms that regulate …

The periodontal ligament (PDL) contains mesenchymal stem cells (MSCs) that can
differentiate into osteoblasts, cementoblasts, and fibroblasts. Nevertheless, the distribution …