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Environmental pollutants: genetic damage and epigenetic changes in male germ cells
About a quarter of the human diseases occurs for exposure to air pollution. The male
reproductive system, and especially spermatogenesis, seems to be particularly sensitive. As …
reproductive system, and especially spermatogenesis, seems to be particularly sensitive. As …
A unique regulatory phase of DNA methylation in the early mammalian embryo
DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
Environmentally induced epigenetic transgenerational inheritance of male infertility
Decreasing male fertility has been observed for the past fifty years. Examples of affected
reproductive parameters include decreases in sperm count and sperm quality and increases …
reproductive parameters include decreases in sperm count and sperm quality and increases …
Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility
Abstract STUDY QUESTION Are there DNA methylation alterations in sperm that could
explain the reduced biological fertility of male partners from couples with unexplained …
explain the reduced biological fertility of male partners from couples with unexplained …
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis
Little is known about how patterns of DNA methylation change during mammalian
spermatogenesis. 5hmC has been recognized as a stable intermediate of DNA …
spermatogenesis. 5hmC has been recognized as a stable intermediate of DNA …
A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells
R Ohno, M Nakayama, C Naruse, N Okashita… - …, 2013 - journals.biologists.com
Germline cells reprogramme extensive epigenetic modifications to ensure the cellular
totipotency of subsequent generations and to prevent the accumulation of epimutations …
totipotency of subsequent generations and to prevent the accumulation of epimutations …
Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA
S Matsuda, T Yasukawa, Y Sakaguchi, K Ichiyanagi… - Scientific reports, 2018 - nature.com
Abstract Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in
mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains …
mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains …
Transposable elements as genetic accelerators of evolution: contribution to genome size, gene regulatory network rewiring and morphological innovation
H Nishihara - Genes & Genetic Systems, 2019 - jstage.jst.go.jp
In the current era, as a growing number of genome sequence assemblies have been
reported in animals, an in-depth analysis of transposable elements (TEs) is one of the most …
reported in animals, an in-depth analysis of transposable elements (TEs) is one of the most …
Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
T Ichiyanagi, K Ichiyanagi, M Miyake… - Nucleic acids …, 2013 - academic.oup.com
DNA methylation is a well-characterized epigenetic modification involved in gene regulation
and transposon silencing in mammals. It mainly occurs on cytosines at CpG sites but …
and transposon silencing in mammals. It mainly occurs on cytosines at CpG sites but …
Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
K Fukuda, C Shimura, H Miura, A Tanigawa… - Communications …, 2021 - nature.com
Histone H3 lysine 9 dimethylation (H3K9me2) is a highly conserved silencing epigenetic
mark. Chromatin marked with H3K9me2 forms large domains in mammalian cells and …
mark. Chromatin marked with H3K9me2 forms large domains in mammalian cells and …