[HTML][HTML] The SLC25 mitochondrial carrier family: structure and mechanism

JJ Ruprecht, ERS Kunji - Trends in biochemical sciences, 2020 - cell.com
Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino
acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the …

The SLC25 carrier family: important transport proteins in mitochondrial physiology and pathology

ERS Kunji, MS King, JJ Ruprecht… - …, 2020 - journals.physiology.org
Members of the mitochondrial carrier family (SLC25) transport a variety of compounds
across the inner membrane of mitochondria. These transport steps provide building blocks …

The molecular mechanism of transport by the mitochondrial ADP/ATP carrier

JJ Ruprecht, MS King, T Zögg, AA Aleksandrova… - Cell, 2019 - cell.com
Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP
synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix …

Inorganic polyphosphates as storage for and generator of metabolic energy in the extracellular matrix

WEG Müller, HC Schröder, X Wang - Chemical reviews, 2019 - ACS Publications
Inorganic polyphosphates (polyP) consist of linear chains of orthophosphate residues,
linked by high-energy phosphoanhydride bonds. They are evolutionarily old biopolymers …

Structural basis for the binding of DNP and purine nucleotides onto UCP1

Y Kang, L Chen - Nature, 2023 - nature.com
Abstract Uncoupling protein 1 (UCP1) conducts protons through the inner mitochondrial
membrane to uncouple mitochondrial respiration from ATP production, thereby converting …

Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies

C Chipot, F Dehez, JR Schnell, N Zitzmann… - Chemical …, 2018 - ACS Publications
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

Hem25p is required for mitochondrial IPP transport in fungi

J Tai, RM Guerra, SW Rogers, Z Fang… - Nature cell …, 2023 - nature.com
Coenzyme Q (CoQ, ubiquinone) is an essential cellular cofactor composed of a redox-active
quinone head group and a long hydrophobic polyisoprene tail. How mitochondria access …

[HTML][HTML] The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism

PG Crichton, Y Lee, ERS Kunji - Biochimie, 2017 - Elsevier
Abstract Uncoupling protein 1 (UCP1) is an integral membrane protein found in the
mitochondrial inner membrane of brown adipose tissue, and facilitates the process of non …

[HTML][HTML] The transport mechanism of the mitochondrial ADP/ATP carrier

ERS Kunji, A Aleksandrova, MS King, H Majd… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the
mitochondrial matrix, which are key transport steps for oxidative phosphorylation in …

Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a **-pong kinetic mechanism

C Cimadamore-Werthein, MS King… - The EMBO …, 2024 - embopress.org
Members of the SLC25 mitochondrial carrier family link cytosolic and mitochondrial
metabolism and support cellular maintenance and growth by transporting compounds …