Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …

Significance: Traumatic injury elicits a complex, dynamic, multidimensional inflammatory
response that is intertwined with complications such as multiple organ dysfunction and …

A First Course in Systems Biology is an introduction for advanced undergraduate and
graduate students to the growing field of systems biology. Its main focus is the development …

Acute liver failure (ALF) represents the most severe damage an organ can sustain and can
lead to shock, coagulopathy, altered mentation, cerebral edema, renal failure, infection, and …

Background We hypothesized that the risk of brain damage in extremely preterm neonates
increases with the breadth and type of systemic inflammation, indexed by the number of …

Background Complex biological processes such as acute inflammation induced by
trauma/hemorrhagic shock/(T/HS) are dynamic and multi-dimensional. We utilized …

In systems biology, researchers aim to understand complex biological systems as a whole,
which is often achieved by mathematical modelling and the analyses of high-throughput …

Atherosclerosis (AS) is a chronic inflammation, which is a major cause of morbidity and
mortality in the world. Accumulative evidences have demonstrated that miRNAs exert crucial …

Objective: To gain insights into individual variations in acute inflammation and physiology.
Design: Large-animal study combined with mathematical modeling. Setting: Academic large …

Background Anopheles gambiae is the primary mosquito vector of human malaria parasites
in sub-Saharan Africa. To date, three innate immune signaling pathways, including the …