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Biology and therapeutic targeting of vascular endothelial growth factor A
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …
process in which several families of regulators have been implicated. Among these, vascular …
Vascular endothelial cell development and diversity
Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …
in the development and maintenance of the functional circulatory system and provide …
Single-cell transcriptomics for the assessment of cardiac disease
Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
Origin and function of activated fibroblast states during zebrafish heart regeneration
The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …
composition of the regenerative niche has remained largely elusive. Here, we dissected the …
Single-cell RNA sequencing unveils unique transcriptomic signatures of organ-specific endothelial cells
Background: Endothelial cells (ECs) display considerable functional heterogeneity
depending on the vessel and tissue in which they are located. Whereas these functional …
depending on the vessel and tissue in which they are located. Whereas these functional …
[HTML][HTML] Progress in multicellular human cardiac organoids for clinical applications
Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq
Immune cells in atherosclerosis include T, B, natural killer (NK) and NKT cells,
macrophages, monocytes, dendritic cells (DCs), neutrophils, and mast cells. Advances in …
macrophages, monocytes, dendritic cells (DCs), neutrophils, and mast cells. Advances in …
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity
Obesity promotes diverse pathologies, including atherosclerosis and dementia, which
frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has …
frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has …
Multiomics network medicine approaches to precision medicine and therapeutics in cardiovascular diseases
Cardiovascular diseases (CVD) are the leading cause of death worldwide and display
complex phenotypic heterogeneity caused by many convergent processes, including …
complex phenotypic heterogeneity caused by many convergent processes, including …
PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle
Background: Left ventricular noncompaction cardiomyopathy (LVNC) was discovered half a
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …