The nexus between RNA-binding proteins and their effectors
RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …
molecule, from its production to its destruction. Whereas much has been learned about RNA …
[HTML][HTML] Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects
N Jiang, W Li, S Jiang, M **, L Bin, Z Yanghe, L Yao… - Biomedicine & …, 2023 - Elsevier
The CREB3 family of proteins, encompassing CREB3 and its four homologs (CREB3L1,
CREB3L2, CREB3L3, and CREB3L4), exerts pivotal control over cellular protein metabolism …
CREB3L2, CREB3L3, and CREB3L4), exerts pivotal control over cellular protein metabolism …
Liquid–liquid phase separation in diseases
X Zhang, L Yuan, W Zhang, Y Zhang, Q Wu, C Li… - MedComm, 2024 - Wiley Online Library
Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can
sequester molecules to implement physiological and pathological functions. LLPS …
sequester molecules to implement physiological and pathological functions. LLPS …
pyPAGE: A framework for Addressing biases in gene-set enrichment analysis—A case study on Alzheimer's disease
Inferring the driving regulatory programs from comparative analysis of gene expression data
is a cornerstone of systems biology. Many computational frameworks were developed to …
is a cornerstone of systems biology. Many computational frameworks were developed to …
Acetylation of PGK1 at lysine 323 promotes glycolysis, cell proliferation, and metastasis in luminal A breast cancer cells
X Gao, T Pan, Y Gao, W Zhu, L Liu, W Duan, C Han… - BMC cancer, 2024 - Springer
Background In prior research employing iTRAQ (Isobaric Tags for Relative and Absolute
Quantitation) technology, we identified a range of proteins in breast cancer tissues exhibiting …
Quantitation) technology, we identified a range of proteins in breast cancer tissues exhibiting …
Exploring the landscape of post-translational modification in drug discovery
Y Cao, T Yu, Z Zhu, Y Zhang, S Sun, N Li, C Gu… - Pharmacology & …, 2024 - Elsevier
Post-translational modifications (PTMs) play a crucial role in regulating protein function, and
their dysregulation is frequently associated with various diseases. The emergence of …
their dysregulation is frequently associated with various diseases. The emergence of …
HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
Secreted protein acidic and rich in cysteine (SPARC), a conserved secreted glycoprotein,
plays crucial roles in regulating various biological processes. SPARC is highly expressed …
plays crucial roles in regulating various biological processes. SPARC is highly expressed …
[HTML][HTML] EWSR1::ATF1 Translocation: A Common Tumor Driver of Distinct Human Neoplasms
Cancer is among the leading causes of mortality in developed countries due to limited
available therapeutic modalities and high rate of morbidity. Although malignancies might …
available therapeutic modalities and high rate of morbidity. Although malignancies might …
Elevated N1-Acetylspermidine Levels in Doxorubicin-treated MCF-7 Cancer Cells: Histone Deacetylase 10 Inhibition with an N1-Acetylspermidine Mimetic
Cancer drug resistance is associated with metabolic adaptation. Cancer cells have been
shown to implicate acetylated polyamines in adaptations during cell death. However …
shown to implicate acetylated polyamines in adaptations during cell death. However …