Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

A recent case report described an individual who was a homozygous carrier of the APOE3
Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease …

While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …