The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network
of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular …

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of proteins involved in lipid homeostasis and …

Heparan sulfate (HS) regulation of FGFR function, which is essential for salivary gland (SG)
development, is determined by the immense structural diversity of sulfated HS domains. 3-O …

Background: Endothelial dysfunction during hemorrhagic shock (HS) is associated with loss
of cell-associated syndecan-1 (Sdc1) and hyperpermeability. Fresh frozen plasma (FFP) …

Introduction Dysregulated inflammation and coagulation are underlying mechanisms driving
organ injury after trauma and hemorrhagic shock. Heparan sulfates, cell surface …

Heparan sulfate is a widely expressed polysaccharide in the extracellular matrix and on the
cell surface. 3-O-sulfated heparan sulfate represents only a small percentage of heparan …

Background: Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is
tempered by concerns about their portability to diverse ancestry groups, thus motivating …

Heparan sulfate proteoglycans (HSPGs) reside in most cells; on their surface, in the
pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity …

Chronic hepatitis B virus (HBV) infection is the major etiology of hepatocellular carcinoma
(HCC), frequently with HBV integrating into the host genome. HBV integration, found in 85 …

Abstract Purpose of the Review The amyloid cascade hypothesis has shaped the
Alzheimer's disease (AD) research field for the last 30 years. Originally hinged on mutations …