Bacteriophages and other mobile genetic elements (MGEs) pose a significant threat to
bacteria, subjecting them to constant attacks. In response, bacteria have evolved a …

Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation
through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on …

The co-evolution of prokaryotes, phages and mobile genetic elements (MGEs) has driven
the diversification of defense and anti-defense systems alike. Anti-defense proteins have …

Bacteria possess (bacterio) phage defence systems to ensure their survival. The
thermophilic lactic acid bacterium, Streptococcus thermophilus, which is used in dairy …

Hachiman is a broad-spectrum antiphage defense system of unknown function. We show
here that Hachiman comprises a heterodimeric nuclease-helicase complex, HamAB. HamA …

The biological interplay between phages and bacteria has driven the evolution of phage anti-
defence systems (ADSs), which evade bacterial defence mechanisms. These ADSs bind …

Bacteria encode various DNA repair pathways to maintain genome integrity. However, the
high degree of homology between DNA repair proteins or their domains hampers accurate …

Integrons are genetic systems that accelerate bacterial adaptation by acquiring and shuffling
gene cassettes. Mobile integrons spread antibiotic resistance genes among bacteria, while …

Bacteria possess numerous defense systems against phage infections, which limit phage
infectivity and pose challenges for phage therapy. This study aimed to engineer phages …

Bacteria and their predatory viruses (bacteriophages or phages) are in a perpetual
molecular arms race. This has led to the evolution of numerous phage defensive systems in …