Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Malignant pure mesenchymal uterine tumours encompass endometrial stromal sarcoma
(ESS), uterine leiomyosarcoma, and undifferentiated sarcomas. This Review discusses …

The continuous growth of advanced malignancies almost universally correlates with the
reactivation of telomerase. While there is still a great deal of basic and applied research to …

Leiomyosarcoma is one of the most frequent soft tissue sarcomas, with an estimated
incidence ranging between 10% and 20% of all newly diagnosed soft tissue sarcomas …

A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT
and PDGFR α. These so-called wild-type (WT) GISTs tend to be less responsive to imatinib …

Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and
molecular heterogeneity. We used integrative molecular profiling to discover and …

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with poorly
characterized genetics. We performed high resolution comparative genomic hybridization on …

Gastrointestinal stromal tumor (GIST) has emerged as a clinically distinct type of sarcoma
with frequent overexpression and mutation of the c-Kit oncogene and a favorable response …

Abstract DOG1 (discovered on GIST 1), known also as TMEM16A and ANO1, has emerged
in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was …

Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth
muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a …