Drug-resistant tuberculosis: a persistent global health concern
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
Drug resistance mechanisms and novel drug targets for tuberculosis therapy
Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
[BOOK][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
Molecular detection of mutations associated with first-and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium …
PJ Campbell, GP Morlock, RD Sikes… - Antimicrobial agents …, 2011 - Am Soc Microbiol
The emergence of multi-and extensively drug-resistant tuberculosis is a significant
impediment to the control of this disease because treatment becomes more complex and …
impediment to the control of this disease because treatment becomes more complex and …
First Succinyl-Proteome Profiling of Extensively Drug-Resistant Mycobacterium tuberculosis Revealed Involvement of Succinylation in Cellular Physiology
L **e, W Liu, Q Li, S Chen, M Xu, Q Huang… - Journal of proteome …, 2015 - ACS Publications
Protein lysine succinylation, an emerging protein post-translational modification widespread
among eukaryotic and prokaryotic cells, represents an important regulator of cellular …
among eukaryotic and prokaryotic cells, represents an important regulator of cellular …
Tuberculosis drug development: history and evolution of the mechanism-based paradigm
S Chakraborty, KY Rhee - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Modern tuberculosis (TB) chemotherapy is widely viewed as a crowning triumph of anti-
infectives research. However, only one new TB drug has entered clinical practice in the past …
infectives research. However, only one new TB drug has entered clinical practice in the past …
Performance Assessment of the GenoType MTBDRsl Test and DNA Sequencing for Detection of Second-Line and Ethambutol Drug Resistance among Patients …
WL Huang, TL Chi, MH Wu, R Jou - Journal of clinical …, 2011 - Am Soc Microbiol
The GenoType MTBDR sl test and DNA sequencing were used to rapidly detect second-line
drug-and ethambutol (EMB)-resistant Mycobacterium tuberculosis. The ability of these two …
drug-and ethambutol (EMB)-resistant Mycobacterium tuberculosis. The ability of these two …
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis
H Nebenzahl-Guimaraes, KR Jacobson… - Journal of …, 2014 - academic.oup.com
Background Improving our understanding of the relationship between the genotype and the
drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more …
drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more …
Mutations within embCAB Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China
Q Sun, T **ao, H Liu, X Zhao, Z Liu, Y Li… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in
embCAB are known to confer most EMB resistance. However, the knowledge about the …
embCAB are known to confer most EMB resistance. However, the knowledge about the …
Molecular Analysis of the embCAB Locus and embR Gene Involved in Ethambutol Resistance in Clinical Isolates of Mycobacterium tuberculosis in France
F Brossier, W Sougakoff, C Bernard… - Antimicrobial Agents …, 2015 - Am Soc Microbiol
Modification of codon 306 in embB is regarded as the main mechanism leading to
ethambutol (ETB) resistance in clinical isolates of Mycobacterium tuberculosis. However …
ethambutol (ETB) resistance in clinical isolates of Mycobacterium tuberculosis. However …