Recent advancements in deciphering the therapeutic properties of plant secondary metabolites: phenolics, terpenes, and alkaloids

B Hilal, MM Khan, Q Fariduddin - Plant Physiology and Biochemistry, 2024 - Elsevier
Plants produce a diverse range of secondary metabolites that serve as defense compounds
against a wide range of biotic and abiotic stresses. In addition, their potential curative …

A review on anti-nutritional factors: Unraveling the natural gateways to human health

R Salim, IB Nehvi, RA Mir, A Tyagi, S Ali… - Frontiers in Nutrition, 2023 - frontiersin.org
Humans are constantly facing multiple health challenges from both communicable and non-
communicable diseases that significantly affect their health. Additionally, drug resistance or …

Potential roles of gut microbes in biotransformation of natural products: An overview

Y Zhao, X Zhong, J Yan, C Sun, X Zhao… - Frontiers in …, 2022 - frontiersin.org
Natural products have been extensively applied in clinical practice, characterized by multi-
component and multi-target, many pharmacodynamic substances, complex action …

Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses

A Hegazy, SH Mahmoud, YAMM Elshaier… - Scientific Reports, 2023 - nature.com
The persistent evolution of drug-resistant influenza strains represents a global concern. The
innovation of new treatment approaches through drug screening strategies and investigating …

Development of a new drug candidate for the inhibition of Lassa virus glycoprotein and nucleoprotein by modification of evodiamine as promising therapeutic agents

S Akash, J Baeza, S Mahmood, N Mukerjee… - Frontiers in …, 2023 - frontiersin.org
The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe
hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or …

Identifying plant-derived antiviral alkaloids as dual inhibitors of SARS-CoV-2 main protease and spike glycoprotein through computational screening

R Yamin, I Ahmad, H Khalid, A Perveen… - Frontiers in …, 2024 - frontiersin.org
COVID-19 is currently considered the ninth-deadliest pandemic, spreading through direct or
indirect contact with infected individuals. It has imposed a consistent strain on both the …

Natural products in attenuating renal inflammation via inhibiting the NLRP3 inflammasome in diabetic kidney disease

Y Wang, Z Sui, M Wang, P Liu - Frontiers in Immunology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is a prevalent and severe complications of diabetes and
serves as the primary cause of end-stage kidney disease (ESKD) globally. Increasing …

The role and mechanism of TCM in the prevention and treatment of infectious diseases

Q Zou, Y Chen, H Qin, R Tang, T Han, Z Guo… - Frontiers in …, 2023 - frontiersin.org
The constant presence of infectious diseases poses an everlasting threat to the entire world.
In recent years, there has been an increased attention toward the application of traditional …

Potential of deep eutectic solvents in the extraction of organic compounds from food industry by-products and agro-industrial waste

M Molnar, D Gašo-Sokač, M Komar… - Separations, 2024 - mdpi.com
Global food waste has a huge impact on the environment, as it is a source of greenhouse
gas emissions and wasted natural resources. Across the world, over 30% of food is lost or …

Medicinal plants against viral infections: a review of metabolomics evidence for the antiviral properties and potentials in plant sources

WB Adeosun, DT Loots - Viruses, 2024 - mdpi.com
Most plants have developed unique mechanisms to cope with harsh environmental
conditions to compensate for their lack of mobility. A key part of their co** mechanisms is …