Dynamic DNA nanotechnology involves the creation of nanoscale devices made of DNA
whose primary function arises from their ability to undergo controlled motion or …

Rare events are processes that occur upon the emergence of unlikely fluctuations. Unlike
what their name suggests, rare events are fairly ubiquitous in nature, as the occurrence of …

Toehold-mediated strand displacement (TMSD) has been used extensively for molecular
sensing and computing in DNA-based molecular circuits. As these circuits grow in …

The series of RNA folding events that occur during transcription can critically influence
cellular RNA function. Here, we present reconstructing RNA dynamics from data (R2D2), a …

Cell-free biosensors are powerful platforms for monitoring human and environmental health.
Here, we expand their capabilities by interfacing them with toehold-mediated strand …

As CRISPR technology is promoted to more fine-divided molecular biology applications, its
inherent performance finds it increasingly difficult to cope with diverse needs in these …

Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA
splicing. Chemical modulation of intron selection has emerged as a route for cancer therapy …

Engineered molecular circuits that process information in biological systems could address
emerging human health and biomanufacturing needs. However, such circuits can be difficult …

DNA/RNA strand displacement is one of the most fundamental reactions in DNA and RNA
circuits and nanomachines. In this work, we reported an exploration of the dynamic process …

Abstract The S. pyogenes (Sp) Cas9 endonuclease is an important gene-editing tool. Sp
Cas9 is directed to target sites based on complementarity to a complexed single-guide RNA …