Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …

Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies
low back pain. Overloading-induced cell death, especially endogenous stem cell death, is …

Degenerated endplate appears with cheese-like morphology and sensory innervation,
contributing to low back pain and subsequently inducing intervertebral disc degeneration in …

Mechanical stimulation plays a crucial part in the development of intervertebral disc
degeneration (IDD). Extracellular matrix (ECM) stiffness, which is a crucial mechanical …

Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major
social and economic burdens; however, its underlying molecular mechanisms remain poorly …

The skeletal system, which contains bones, joints, tendons, ligaments and other elements,
plays a wide variety of roles in body sha**, support and movement, protection of internal …

Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP)
cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells …

Intervertebral disc degeneration (IDD), characterized as decreased proteoglycan content,
ossification of endplate, and decreased intervertebral height, is one of the major reasons of …

Spinal pain is a major clinical problem, however, its origins and underlying mechanisms
remain unclear. Here we report that in mice, osteoclasts induce sensory innervation in the …