The design of reversible hydrogels to capture extracellular matrix dynamics

AM Rosales, KS Anseth - Nature Reviews Materials, 2016 - nature.com
The extracellular matrix (ECM) is a dynamic environment that constantly provides physical
and chemical cues to embedded cells. Much progress has been made in engineering …

Composition, structure and function of the corneal stroma

EM Espana, DE Birk - Experimental eye research, 2020 - Elsevier
No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics

MS Islam, A Ciavattini, F Petraglia… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies

CH Ong, CL Tham, HH Harith, N Firdaus… - European journal of …, 2021 - Elsevier
Transforming growth factor-beta (TGF-β) plays multiple homeostatic roles in the regulation of
inflammation, proliferation, differentiation and would healing of various tissues. Many studies …

TGF-β family signaling in mesenchymal differentiation

I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

[HTML][HTML] Immunomodulatory role of the extracellular matrix within the liver disease microenvironment

CE McQuitty, R Williams, S Chokshi… - Frontiers in …, 2020 - frontiersin.org
Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Beyond tissue injury—damage-associated molecular patterns, Toll-like receptors, and inflammasomes also drive regeneration and fibrosis

HJ Anders, L Schaefer - Journal of the American Society of …, 2014 - journals.lww.com
Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

[HTML][HTML] Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction

L Schaefer, RV Iozzo - Journal of Biological Chemistry, 2008 - Elsevier
The small leucine-rich proteoglycan (SLRP) family has significantly expanded in the past
decade to now encompass five discrete classes, grouped by common structural and …

The 12th–14th type III repeats of fibronectin function as a highly promiscuous growth factor‐binding domain

MM Martino, JA Hubbell - The FASEB Journal, 2010 - Wiley Online Library
It has recently been shown that some growth factors (GFs) have strong interactions with
nonproteoglycan extracellular matrix proteins. Relevant here, the 12th‐14th type three …

Dynamics of the skeletal muscle secretome during myoblast differentiation

J Henningsen, KTG Rigbolt, B Blagoev… - Molecular & cellular …, 2010 - mcponline.org
During recent years, increased efforts have focused on elucidating the secretory function of
skeletal muscle. Through secreted molecules, skeletal muscle affects local muscle biology in …