Childhood obesity and the associated rise in cardiometabolic complications

S Caprio, N Santoro, R Weiss - Nature metabolism, 2020 - nature.com
Childhood obesity is one of the most serious global public-health challenges of the twenty-
first century. Over the past four decades, the number of children and adolescents with …

Molecular mechanisms of obesity-linked cardiac dysfunction: an up-date on current knowledge

J Gutiérrez-Cuevas, A Sandoval-Rodriguez… - Cells, 2021 - mdpi.com
Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly
tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals …

Assessing the relationship between systemic immune-inflammation index and metabolic syndrome in children with obesity

DM Nicoară, AI Munteanu, AC Scutca, N Mang… - International Journal of …, 2023 - mdpi.com
Childhood obesity represents a worldwide concern as many countries have reported an
increase in its incidence, with possible cardiovascular long-term implications. The …

Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies

D Aune, A Sen, S Schlesinger, T Norat… - European journal of …, 2017 - Springer
Different adiposity measures have been associated with increased risk of atrial fibrillation,
however, results have previously only been summarized for BMI. We therefore conducted a …

Highlights of mechanisms and treatment of obesity-related hypertension

E Shams, V Kamalumpundi, J Peterson… - Journal of human …, 2022 - nature.com
The prevalence of obesity has increased two to three times from 1975 to 2015. Large-scale
epidemiological and longitudinal prospective studies link obesity with hypertension …

Anti-inflammatory effects of melatonin in obesity and hypertension

NJ Prado, L Ferder, W Manucha, ER Diez - Current hypertension reports, 2018 - Springer
Abstract Purpose of Review Here, we review the known relations between hypertension and
obesity to inflammation and postulate the endogenous protective effect of melatonin and its …

Body mass index, abdominal fatness, and the risk of sudden cardiac death: a systematic review and dose–response meta-analysis of prospective studies

D Aune, S Schlesinger, T Norat, E Riboli - European journal of …, 2018 - Springer
Although overweight and obesity are established risk factors for some types of heart disease
including ischemic heart disease, heart failure and atrial fibrillation, less is known about the …

Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy

AS Pereyra, LY Hasek, KL Harris, AG Berman… - Journal of Biological …, 2017 - jbc.org
Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis
of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial …

[HTML][HTML] Cardiovascular risk factors in children with obesity, preventive diagnostics and possible interventions

M Močnik, N Marčun Varda - Metabolites, 2021 - mdpi.com
The increasing burden of obesity plays an essential role in increased cardiovascular
morbidity and mortality. The effects of obesity on the cardiovascular system have also been …

Monitoring and management of hypertension with obesity in adolescents

B Falkner - Integrated blood pressure control, 2017 - Taylor & Francis
Largely due to the childhood obesity epidemic, there has been an increase in the
prevalence of hypertension in children and adolescents. Obesity associated hypertension is …