Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …

Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based
chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage …

Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …

A defining hallmark of tumor phenotypes is uncontrolled cell proliferation, while fermentative
glycolysis has long been considered as one of the major metabolic pathways that allows …

Abstract Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a
small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the …