Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal
Metastatic cancer is rarely cured by current DNA damaging treatments, apparently due to the
development of resistance. However, recent data indicates that tumour cells can elicit the …
development of resistance. However, recent data indicates that tumour cells can elicit the …
The molecular and cellular strategies of glioblastoma and non-small-cell lung cancer cells conferring radioresistance
Ionizing radiation (IR) has been shown to play a crucial role in the treatment of glioblastoma
(GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies …
(GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies …
CellSegm - a MATLAB toolbox for high-throughput 3D cell segmentation
The application of fluorescence microscopy in cell biology often generates a huge amount of
imaging data. Automated whole cell segmentation of such data enables the detection and …
imaging data. Automated whole cell segmentation of such data enables the detection and …
Cell segmentation, tracking, and mitosis detection using temporal context
F Yang, MA Mackey, F Ianzini, G Gallardo… - … Conference on Medical …, 2005 - Springer
Abstract The Large Scale Digital Cell Analysis System (LSDCAS) developed at the
University of Iowa provides capabilities for extended-time live cell image acquisition. This …
University of Iowa provides capabilities for extended-time live cell image acquisition. This …
Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe
Cancer is frequently characterized histologically by the appearance of large cells that are
either aneuploid or polyploid. Aneuploidy and polyploidy are hallmarks of radiation-induced …
either aneuploid or polyploid. Aneuploidy and polyploidy are hallmarks of radiation-induced …
Segregation of genomes in polyploid tumour cells following mitotic catastrophe
Following irradiation p53‐function‐deficient tumour cells undergo mitotic catastrophe and
form endopolyploid cells. A small proportion of these segregates nuclei, and give rise to …
form endopolyploid cells. A small proportion of these segregates nuclei, and give rise to …
Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe
Background We have previously reported that p53 mutated radioresistant lymphoma cell
lines undergo mitotic catastrophe after irradiation, resulting in metaphase arrest and the …
lines undergo mitotic catastrophe after irradiation, resulting in metaphase arrest and the …
Mitotic catastrophe and endomitosis in tumour cells: an evolutionary key to a molecular solution
Following genotoxic insult, p53 mutated tumour cells undergo mitotic catastrophe. This is
characterised by a switch from mitosis to the endocycle. The essential difference between …
characterised by a switch from mitosis to the endocycle. The essential difference between …
The role of meiotic cohesin REC8 in chromosome segregation in γ irradiation-induced endopolyploid tumour cells
Escape from mitotic catastrophe and generation of endopolyploid tumour cells (ETCs)
represents a potential survival strategy of tumour cells in response to genotoxic treatments …
represents a potential survival strategy of tumour cells in response to genotoxic treatments …
Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells
F Ianzini, A Bertoldo, EA Kosmacek, SL Phillips… - Cancer cell …, 2006 - Springer
Background We have demonstrated that in some human cancer cells both chronic mild heat
and ionizing radiation exposures induce a transient block in S and G2 phases of the cell …
and ionizing radiation exposures induce a transient block in S and G2 phases of the cell …