Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial
cells. These transcription regulators are responsible for many important cellular processes …

Microbes exhibit remarkable adaptability to environmental fluctuations. Signaling
mechanisms, such as two-component systems and secondary messengers, have long been …

Nucleoid‐associated protein HU, a conserved protein across eubacteria is necessary for
maintaining the nucleoid organization and global regulation of gene expression …

There is increasing evidence that phenotypically drug-resistant bacteria may be important
determinants of antibiotic treatment failure. Using high-throughput imaging, we defined …

Metal ions are essential trace elements for all living organisms and play critical catalytic,
structural, and allosteric roles in many enzymes and transcription factors. Mycobacterium …

Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

Genomes of all organisms are persistently threatened by endogenous and exogenous
assaults. Bacterial mechanisms of genome maintenance must provide protection throughout …

Despite the tremendous improvement in overall global health heralded by the adoption of
the Millennium Declaration in the year 2000, tropical infections remain a major health …

Twelve novel substituted isatin-propylene-1H-1, 2, 3-triazole-4-methylene-moxifloxacin
hybrids 5a-l were designed, synthesized and screened for their in vitro anti-mycobacterial …

The rising threat of antibiotic resistance in pathogenic bacteria emphasizes the need for new
therapeutic strategies. This review focuses on bacterial transcription factors (TFs), which …