The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …

Thorough research on HIV is progressively enabling us to understand the intricate
mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and …

Background Inadequate reconstitution of CD4+ T lymphocytes is an important clinical
problem complicating chemotherapy, human immunodeficiency virus infection, and bone …

A complex array of multiphasic and multifactorial immunopathogenic mechanisms are
involved in the establishment and progression of human immunodeficiency virus (HIV) …

▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …

As the primary site of T‐cell development, the thymus plays a key role in the generation of a
strong yet self‐tolerant adaptive immune response, essential in the face of the potential …

▪ Abstract Human immunodeficiency virus-1 (HIV-1) is usually transmitted through sexual
contact and in the very early stages of infection establishes a persistent infection in …

Rapid recovery of CD4+ T cells after intensive chemotherapy is limited by an age-dependent
decline in thymopoiesis. Here we sought to determine whether similar limitations exist for …

The human thymus is a complex chimeric organ comprised of central (thymic epithelial
space) and peripheral (perivascular space) components that functions well into adult life to …

The hallmark of HIV-1 and SIV infections is CD4+ T cell depletion. Both direct cell killing and
indirect mechanisms related to immune activation have been suggested to cause the …