Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor
microenvironment (TME) and influence cancer hallmarks, but without systematic …

Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a
crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated …

As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

Cancer-associated fibroblasts (CAFs) play a role in response to cancer treatment and
patient prognosis. CAFs show phenotypic and functional heterogeneity and differ widely in …

To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of
attention in recent years in particular with the advent of clinical successes achieved by …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …