Meiosis: dances between homologs
D Zickler, N Kleckner - Annual Review of Genetics, 2023 - annualreviews.org
The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …
Architecture and dynamics of meiotic chromosomes
SN Ur, KD Corbett - Annual Review of Genetics, 2021 - annualreviews.org
The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …
Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line
R Hinch, P Donnelly, AG Hinch - Science, 2023 - science.org
Meiotic recombination commences with hundreds of programmed DNA breaks; however, the
degree to which they are accurately repaired remains poorly understood. We report that …
degree to which they are accurately repaired remains poorly understood. We report that …
Meiosis in budding yeast
Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …
two meiotic divisions reduce chromosome number by half, typically generating haploid …
A practical reference for studying meiosis in the model ciliate Tetrahymena thermophila
Meiosis is a critical cell division program that produces haploid gametes for sexual
reproduction. Abnormalities in meiosis are often causes of infertility and birth defects (eg …
reproduction. Abnormalities in meiosis are often causes of infertility and birth defects (eg …
Sae2 controls Mre11 endo-and exonuclease activities by different mechanisms
T Tamai, G Reginato, R Ojiri, I Morita, A Avrutis… - Nature …, 2024 - nature.com
DNA double-strand breaks (DSBs) must be repaired to ensure cell survival and genomic
integrity. In yeast, the Mre11-Rad50-Xrs2 complex (MRX) collaborates with Sae2 to initiate …
integrity. In yeast, the Mre11-Rad50-Xrs2 complex (MRX) collaborates with Sae2 to initiate …
The price of human evolution: Cancer-testis antigens, the decline in male fertility and the increase in cancer
The increasing frequency of general and particularly male cancer coupled with the reduction
in male fertility seen worldwide motivated us to seek a potential evolutionary link between …
in male fertility seen worldwide motivated us to seek a potential evolutionary link between …
Concerted cutting by Spo11 illuminates meiotic DNA break mechanics
D Johnson, M Crawford, T Cooper, C Claeys Bouuaert… - Nature, 2021 - nature.com
Genetic recombination arises during meiosis through the repair of DNA double-strand
breaks (DSBs) that are created by Spo11, a topoisomerase-like protein,. Spo11 DSBs form …
breaks (DSBs) that are created by Spo11, a topoisomerase-like protein,. Spo11 DSBs form …
Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30
DNA double-strand breaks (DSBs) are nucleolytically processed to generate single-
stranded DNA for homologous recombination. In Saccharomyces cerevisiae meiosis, this …
stranded DNA for homologous recombination. In Saccharomyces cerevisiae meiosis, this …
Cryo-EM structures of the Spo11 core complex bound to DNA
DNA double-strand breaks that initiate meiotic recombination are formed by the
topoisomerase-relative enzyme Spo11, supported by conserved auxiliary factors. Because …
topoisomerase-relative enzyme Spo11, supported by conserved auxiliary factors. Because …