The prevalence of intrinsically disordered protein regions, particularly in eukaryotic proteins,
and their clear functional advantages for signaling and gene regulation have created an …

Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …

This review describes the latest developments in the field of 17 O NMR spectroscopy of
organic and biological molecules both in aqueous solution and in the solid state. In the first …

In this article, we first designed and synthesized curcumin-based near-infrared (NIR)
fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Aβ) …

The self-assembly of β-amyloid (Aβ) peptides into highly stable plaques is a major hallmark
of Alzheimer's disease. Here, we report visible light-driven dissociation of β-sheet-rich Aβ …

Abstract 17O NMR spectroscopy has been the subject of vivid interest in recent years,
because there is increasing evidence that it can provide unique insight into the structure and …

The brains of Alzheimer's disease patients show a decrease in brain mass and a
preponderance of extracellular Amyloid-β plaques. These plaques are formed by …

The structure of two protected amino acids, FMOC-l-leucine and FMOC-l-valine, and a
dipeptide, N-acetyl-l-valyl-l-leucine (N-Ac-VL), were studied via one-and two-dimensional …

Dynamic nuclear polarization of 17O was studied using four different polarizing agents: the
biradical TOTAPOL and the monoradicals trityl and SA-BDPA, as well as a mixture of the …

Product release is the rate-determining step in the arene syn-dihydroxylation reaction taking
place at Rieske oxygenase enzymes and is regarded as a difficult problem to be resolved in …