Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

The role and applications of extracellular vesicles in osteoporosis

F Fang, J Yang, J Wang, T Li, E Wang, D Zhang, X Liu… - Bone research, 2024 - nature.com
Osteoporosis is a widely observed condition characterized by the systemic deterioration of
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …

[HTML][HTML] Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …

Biological features of extracellular vesicles and challenges

Y Zeng, Y Qiu, W Jiang, J Shen, X Yao, X He… - Frontiers in Cell and …, 2022 - frontiersin.org
Extracellular vesicles (EVs) are vesicles with a lipid bilayer membrane on the outside, which
are widely found in various body fluids and contain biological macromolecules such as …

[HTML][HTML] Extracellular vesicles, inflammation, and cardiovascular disease

A Akhmerov, T Parimon - Cells, 2022 - mdpi.com
Cardiovascular disease is a leading cause of death worldwide. The underlying mechanisms
of most cardiovascular disorders involve innate and adaptive immune responses, and …

Stem cell-derived extracellular vesicles as new tools in regenerative medicine-Immunomodulatory role and future perspectives

E Karnas, P Dudek, EK Zuba-Surma - Frontiers in immunology, 2023 - frontiersin.org
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted
significant attention in the regenerative medicine due to the ability of these cells to proliferate …

[HTML][HTML] Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics

P Gil-Cabrerizo, T Simon-Yarza, E Garbayo… - Advanced Drug Delivery …, 2024 - Elsevier
Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …

Role and therapeutic perspectives of extracellular vesicles derived from liver and adipose tissue in metabolic dysfunction-associated steatotic liver disease

W Li, L Yu - Artificial Cells, Nanomedicine, and Biotechnology, 2024 - Taylor & Francis
The global epidemic of metabolic diseases has led to the emergence of metabolic
dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction …

CRISPR-Cas9 delivery strategies with engineered extracellular vesicles

Y Lu, K Godbout, G Lamothe, JP Tremblay - Molecular Therapy-Nucleic …, 2023 - cell.com
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic
mutations in tissues and cells. Recent progress in the CRISPR-Cas9 systems has led to …

Metabolomics of extracellular vesicles: a future promise of multiple clinical applications

YL Wu, WJ Chen, M Guo, Q Tan, E Zhou… - International …, 2022 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) can contain DNA, RNA, proteins and metabolic molecules from
primary origins; they are coated with a phospholipid bilayer membrane and released by …