Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …

The cytokine responses characterizing the inflammatory bowel diseases are the key
pathophysiologic elements that govern the initiation, evolution, and, ultimately, the resolution …

Abstract Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-
23 to become encephalitogenic, but the mechanism by which IL-23 promotes their …

Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous
system (CNS), which involves autoimmune responses to myelin antigens. Studies in …

IL-17-producing T lymphocytes have been recently shown to comprise a distinct lineage of
proinflammatory T helper cells, termed Th17 cells, that are major contributors to autoimmune …

Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …

Lymphocyte recruitment and activation have been implicated in the progression of cerebral
ischemia-reperfusion (I/R) injury, but the roles of specific lymphocyte subpopulations and …