Activatable small-molecule hydrogen sulfide donors
Significance: Hydrogen sulfide (H2S) is an important biological signaling molecule involved
in many physiological processes. These diverse roles have led researchers to develop …
in many physiological processes. These diverse roles have led researchers to develop …
Perspectives about self-immolative drug delivery systems
Self-immolative drug delivery system is one of the delivery systems, which have drawn
attention, in recent research, highlighting the improvement they generate in drug selectivity …
attention, in recent research, highlighting the improvement they generate in drug selectivity …
Design and Development of a Bioorthogonal, Visualizable and Mitochondria‐Targeted Hydrogen Sulfide (H2S) Delivery System
Y Chen, R Zhao, C Tang, C Zhang, W Xu… - Angewandte …, 2022 - Wiley Online Library
Hydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the targeted
delivery and real‐time feedback of exogenous H2S are still challenging. With the aid of …
delivery and real‐time feedback of exogenous H2S are still challenging. With the aid of …
An innovative hydrogen peroxide‐sensing scaffold and insight towards its potential as an ROS‐activated persulfide donor
RA Hankins, SI Suarez, MA Kalk… - Angewandte Chemie …, 2020 - Wiley Online Library
Reactive sulfur species, such as hydrogen sulfide, persulfides, and polysulfides, have
recently emerged as key signaling molecules and important physiological mediators within …
recently emerged as key signaling molecules and important physiological mediators within …
Targeted delivery of persulfides to the gut: Effects on the microbiome
Persulfides (R− SSH) have been hypothesized as potent redox modulators and signaling
compounds. Reported herein is the synthesis, characterization, and in vivo evaluation of a …
compounds. Reported herein is the synthesis, characterization, and in vivo evaluation of a …
Polymeric persulfide prodrugs: mitigating oxidative stress through controlled delivery of reactive sulfur species
Related biologically to the known gasotransmitter hydrogen sulfide (H2S), persulfides (R–
SSH) have recently been recognized as native signaling compounds and redox regulators …
SSH) have recently been recognized as native signaling compounds and redox regulators …
Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRASG12D Mutation
X Ji, Y Li, X Kong, D Chen, J Lu - ACS omega, 2023 - ACS Publications
Effective oral therapies are urgently required to treat KRASG12D mutant cancers. Therefore,
synthesis and screening were performed for 38 prodrugs of MRTX1133 to identify an oral …
synthesis and screening were performed for 38 prodrugs of MRTX1133 to identify an oral …
The effects of cell culture conditions on premature hydrolysis of traceless ester-linked disulfide linkers
Disulfide acids are important for traceless release mechanisms in prodrugs and drug
delivery applications. Their ability to self-immolate and release cargo due to environmental …
delivery applications. Their ability to self-immolate and release cargo due to environmental …
[HTML][HTML] Nano/microparticles encapsulation via covalent drug conjugation
Advancement in chemistry holds a great promise in improving drug encapsulation that leads
to superior drug delivery efficiency and the therapeutic efficacy of nano/micro-delivery …
to superior drug delivery efficiency and the therapeutic efficacy of nano/micro-delivery …
[PDF][PDF] Development of Gold Nanoparticles for Targeting PD-L1-Presenting Breast Cancers
DJ Blevins - 2023 - dspace.library.uvic.ca
Our goal was to selectively target the immunosuppressive programmed cell death protein
ligand 1 (PD-L1) presenting cancer cells with gold nanoparticles (AuNP). Initially, small …
ligand 1 (PD-L1) presenting cancer cells with gold nanoparticles (AuNP). Initially, small …