Flavonoids as potential agents in the management of type 2 diabetes through the modulation of α-amylase and α-glucosidase activity: a review
C Proença, D Ribeiro, M Freitas… - Critical Reviews in Food …, 2022 - Taylor & Francis
Abstract Type 2 diabetes (T2D) is one of the most prevalent metabolic diseases worldwide
and is characterized by increased postprandial hyperglycemia (PPHG). α-Amylase and α …
and is characterized by increased postprandial hyperglycemia (PPHG). α-Amylase and α …
Anthocyanins as antidiabetic agents—in vitro and in silico approaches of preventive and therapeutic effects
H Oliveira, A Fernandes, N F. Brás, N Mateus… - Molecules, 2020 - mdpi.com
Many efforts have been made in the past two decades into the search for novel natural and
less-toxic anti-diabetic agents. Some clinical trials have assigned this ability to …
less-toxic anti-diabetic agents. Some clinical trials have assigned this ability to …
Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
XY Deng, JJ Ke, YY Zheng, DL Li, K Zhang… - Journal of Enzyme …, 2022 - Taylor & Francis
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised
to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA …
to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA …
Bee venom—a potential complementary medicine candidate for SARS-CoV-2 infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by severe
cytokine storm syndrome following inflammation. SARS-CoV-2 directly interacts with …
cytokine storm syndrome following inflammation. SARS-CoV-2 directly interacts with …
The metal dependence of single-metal mediated phosphodiester bond cleavage: a QM/MM study of a multifaceted human enzyme
R Kaur, MM Aboelnga, DJ Nikkel… - Physical Chemistry …, 2022 - pubs.rsc.org
Nucleases catalyze the cleavage of phosphodiester bonds in nucleic acids using a range of
metal cofactors. Although it is well accepted that many nucleases rely on two metal ions, the …
metal cofactors. Although it is well accepted that many nucleases rely on two metal ions, the …
Design, synthesis, spectroscopic characterizations, antidiabetic, in silico and kinetic evaluation of novel curcumin-fused aldohexoses
Abstract Curcumin (bis-α, β-unsaturated β-diketone) plays an important role in the
prevention of numerous diseases, including diabetes. Curcumin, as an enzyme inhibitor …
prevention of numerous diseases, including diabetes. Curcumin, as an enzyme inhibitor …
Computational study of asian propolis compounds as potential anti-type 2 diabetes mellitus agents by using inverse virtual screening with the DIA-DB web server …
Propolis contains a wide range of pharmacological activities because of their various
bioactive compounds. The beneficial effect of propolis is interesting for treating type-2 …
bioactive compounds. The beneficial effect of propolis is interesting for treating type-2 …
Modulating the digestibility of cassava starch by esterification with phenolic acids
This study applied ferulic acid, sinapic acid, and p-coumaric acid to synthesise esters with
cassava starch and investigated their digestibility, GI and starch structure alterations. Starch …
cassava starch and investigated their digestibility, GI and starch structure alterations. Starch …
Multitarget Action of Xanthones from Garcinia mangostana against α-Amylase, α-Glucosidase and Pancreatic Lipase
J Cardozo-Muñoz, LE Cuca-Suárez… - Molecules, 2022 - mdpi.com
Digestive enzymes such α-amylase (AA), α-glucosidase (AG) and pancreatic lipase (PL),
play an important role in the metabolism of carbohydrates and lipids, being attractive …
play an important role in the metabolism of carbohydrates and lipids, being attractive …
Computational Exploration of How Enzyme **mE Converts Natural S-Epoxide to Pyran and R-Epoxide to Furan
Enzymes have long been characterized for their specificity and efficiency in catalyzing one
substrate to one product. However, a SnoaL-like cyclase (**mE) that was originally …
substrate to one product. However, a SnoaL-like cyclase (**mE) that was originally …