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Consanguinity, human evolution, and complex diseases
AH Bittles, ML Black - Proceedings of the National Academy of Sciences, 2010 - pnas.org
There is little information on inbreeding during the critical early years of human existence.
However, given the small founding group sizes and restricted mate choices it seems …
However, given the small founding group sizes and restricted mate choices it seems …
Consanguinity and its relevance to clinical genetics
AH Bittles - Clinical genetics, 2001 - Wiley Online Library
Marriage between close biological relatives is generally regarded with suspicion and
distaste within Western society, reflecting historical and religious prejudice. By comparison …
distaste within Western society, reflecting historical and religious prejudice. By comparison …
Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery
Abstract The Greater Middle East (GME) has been a central hub of human migration and
population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf …
population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf …
Genomic runs of homozygosity record population history and consanguinity
M Kirin, R McQuillan, CS Franklin, H Campbell… - PloS one, 2010 - journals.plos.org
The human genome is characterised by many runs of homozygous genotypes, where
identical haplotypes were inherited from each parent. The length of each run is determined …
identical haplotypes were inherited from each parent. The length of each run is determined …
The genetic basis of non-syndromic intellectual disability: a review
L Kaufman, M Ayub, JB Vincent - Journal of neurodevelopmental disorders, 2010 - Springer
Intellectual disability (ID), also referred to as mental retardation (MR), is frequently the result
of genetic mutation. Where ID is present together with additional clinical symptoms or …
of genetic mutation. Where ID is present together with additional clinical symptoms or …
Map** autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families
Approximately 1% of the global population is affected by intellectual disability (ID), and the
majority receive no molecular diagnosis. Previous studies have indicated high levels of …
majority receive no molecular diagnosis. Previous studies have indicated high levels of …
Short report consanguineous marriage in Iran
Consanguineous marriage is a major feature of family systems in south-west Asia. The aim
of the present study was to determine the current prevalence and patterns of consanguinity …
of the present study was to determine the current prevalence and patterns of consanguinity …
Risk factors for low birthweight in the public-hospitals at Peshawar, NWFP-Pakistan
S Badshah, L Mason, K McKelvie, R Payne… - BMC public health, 2008 - Springer
Background Low birthweight is a widely used indicator of newborn health. This study
investigates the association of birthweight< 2.5 kg (LBW) with a wide range of factors related …
investigates the association of birthweight< 2.5 kg (LBW) with a wide range of factors related …
Endogamy, consanguinity and community genetics
AH Bittles - Journal of genetics, 2002 - Springer
The population of India is composed of many thousands of subpopulations, divided by
geography, language, religion and caste or biraderi (patrilineage) boundaries, with …
geography, language, religion and caste or biraderi (patrilineage) boundaries, with …
[PDF][PDF] Regional variations in the prevalence of consanguinity in Saudi Arabia
I Middle, AA Al-Salloum, AS Al-Herbish, MM Qurachi… - Saudi med J, 2007 - fac.ksu.edu.sa
Methods. The data were collected during the period 2004-2005. The Health Profile of Saudi
Children and Adolescent Project provided the opportunity to include questions on …
Children and Adolescent Project provided the opportunity to include questions on …