cAMP‐mediated signaling pathways regulate a multitude of important biological processes
under both physiological and pathological conditions, including diabetes, heart failure and …

At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca2+
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …

Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

Chromaffin cells (CCs) of the adrenal gland and the sympathetic nervous system produce
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …

It has now been over 10 years since efforts to completely understand the signalling actions
of cAMP (3′‐5′‐cyclic adenosine monophosphate) led to the discovery of exchange …

Because prostate cancer is, in its early stages, an androgen-dependent pathology,
treatments aiming at decreasing testosterone plasma concentration have been developed …

Besides controlling a wide variety of cell functions, T-type channels have been shown to
regulate neurotransmitter release in peripheral and central synapses and neuroendocrine …

α1H T‐type channels recruited by β1‐adrenergic stimulation in rat chromaffin cells (RCCs)
are coupled to fast exocytosis with the same Ca2+ dependence of high‐threshold Ca2+ …

Non‐technical summary Glucagon like peptide 1 (GLP‐1) based therapies are now widely
used for the treatment of diabetes. The physiological source of the hormone is the intestinal …

Voltage-gated L-type (Cav1. 2 and Cav1. 3) channels are widely expressed in
cardiovascular tissues and represent the critical drug-target for the treatment of several …