Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics
JD Scott, RM Williams - Chemical Reviews, 2002 - ACS Publications
The antitumor antibiotics belonging to the tetrahydroisoquinoline family have been studied
thoroughly over the past 25 years starting with the isolation of naphthyridinomycin in 1974 …
thoroughly over the past 25 years starting with the isolation of naphthyridinomycin in 1974 …
Dearomative logic in natural product total synthesis
CJ Huck, YD Boyko, D Sarlah - Natural product reports, 2022 - pubs.rsc.org
Covering: 2011 to 2022 The natural world is a prolific source of some of the most interesting,
rare, and complex molecules known, harnessing sophisticated biosynthetic machinery …
rare, and complex molecules known, harnessing sophisticated biosynthetic machinery …
Asymmetric synthesis of isoquinoline alkaloids
M Chrzanowska, MD Rozwadowska - Chemical reviews, 2004 - ACS Publications
Recent methods of the asymmetric synthesis of isoquinoline alkaloids are based generally
on two synthetic strategies: the stereochemical modification of the traditional, classical …
on two synthetic strategies: the stereochemical modification of the traditional, classical …
Development of Yondelis®(trabectedin, ET-743). A semisynthetic process solves the supply problem
C Cuevas, A Francesch - Natural product reports, 2009 - pubs.rsc.org
Covering: up to 2008 Ecteinascidins are marine natural products consisting of two or three
linked tetrahydroisoquinoline subunits and an active carbinolamine functional group. Their …
linked tetrahydroisoquinoline subunits and an active carbinolamine functional group. Their …
Total synthesis of ecteinascidin 743
A Endo, A Yanagisawa, M Abe, S Tohma… - Journal of the …, 2002 - ACS Publications
Total Synthesis of Ecteinascidin 743 | Journal of the American Chemical Society ACS ACS
Publications C&EN CAS Find my institution Log In Journal of the American Chemical Society …
Publications C&EN CAS Find my institution Log In Journal of the American Chemical Society …
Total synthesis of ecteinascidin 743
J Chen, X Chen, M Bois-Choussy… - Journal of the American …, 2006 - ACS Publications
Total Synthesis of Ecteinascidin 743 | Journal of the American Chemical Society ACS ACS
Publications C&EN CAS Find my institution Log In Journal of the American Chemical Society …
Publications C&EN CAS Find my institution Log In Journal of the American Chemical Society …
Novel syntheses of bridge-containing organic compounds
W Zhao - Chemical reviews, 2010 - ACS Publications
Bridge-containing segments exist in numerous natural products and active pharmaceutical
ingredients (API) and intermediates, creating more structural complexity. In addition, bridge …
ingredients (API) and intermediates, creating more structural complexity. In addition, bridge …
Total synthesis of (−)-tetrazomine. Determination of the stereochemistry of tetrazomine and the synthesis and biological activity of tetrazomine analogues
JD Scott, RM Williams - Journal of the American Chemical Society, 2002 - ACS Publications
The first total synthesis of the potent antitumor antibiotic (−)-tetrazomine has been
accomplished. A new method for the formation of the allylic amine precursor to an …
accomplished. A new method for the formation of the allylic amine precursor to an …
New strategy for the synthesis of tetrahydroisoquinoline alkaloids
P Magnus, KS Matthews, V Lynch - Organic Letters, 2003 - ACS Publications
A general strategy for the formation of 1, 3-cis-substituted tetrahydroisoquinolines is
described from ortho-iodo imines involving Larock isoquinoline synthesis, addition of …
described from ortho-iodo imines involving Larock isoquinoline synthesis, addition of …
Advances in the chemistry and pharmacology of ecteinascidins, a promising new class of anticancer agents
I Manzanares, C Cuevas, R Garcia-Nieto… - … -Anti-Cancer Agents, 2001 - ingentaconnect.com
Ecteinascidins are marine natural products consisting of two or three linked
tetrahydroisoquinoline subunits and an active carbinolamine functional group. Their potent …
tetrahydroisoquinoline subunits and an active carbinolamine functional group. Their potent …