The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated
tissue clones whose continued propagation is vested in a biologically distinct subset of cells …

Tissues with defined cellular hierarchies in development and homeostasis give rise to
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …

Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

Human brain tumors appear to have a hierarchical cellular organization suggestive of a
stem cell foundation. In vitro expansion of the putative cancer stem cells as stable cell lines …

Sphere-forming assays have been widely used to retrospectively identify stem cells based
on their reported capacity to evaluate self-renewal and differentiation at the single-cell level …

Macrophages (MΦs)/microglia that constitute the dominant tumor-infiltrating immune cells in
glioblastoma are recruited by tumor-secreted factors and are induced to become …

There is compelling evidence that many solid cancers are organized hierarchically and
contain a small population of cancer stem cells (CSCs). It seems reasonable to suggest that …

Hypoxia promotes the expansion of non-neoplastic stem and precursor cell populations in
the normal brain, and is common in malignant brain tumors. We examined the effects of …

Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive tumors of childhood that are
almost universally fatal. Our understanding of this devastating cancer is limited by a dearth …