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The molecular memory code and synaptic plasticity: A synthesis
SJ Gershman - Biosystems, 2023 - Elsevier
The most widely accepted view of memory in the brain holds that synapses are the storage
sites of memory, and that memories are formed through associative modification of …
sites of memory, and that memories are formed through associative modification of …
The insula and taste learning
The sense of taste is a key component of the sensory machinery, enabling the evaluation of
both the safety as well as forming associations regarding the nutritional value of ingestible …
both the safety as well as forming associations regarding the nutritional value of ingestible …
The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice
Y Wu, C Chen, M Chen, K Qian, X Lv, H Wang… - Nature …, 2020 - nature.com
Reduced food intake is common to many pathological conditions, such as infection and toxin
exposure. However, cortical circuits that mediate feeding responses to these threats are less …
exposure. However, cortical circuits that mediate feeding responses to these threats are less …
Learning depends on the information conveyed by temporal relationships between events and is reflected in the dopamine response to cues
Contemporary theories guiding the search for neural mechanisms of learning and memory
assume that associative learning results from the temporal pairing of cues and reinforcers …
assume that associative learning results from the temporal pairing of cues and reinforcers …
Activity of insula to basolateral amygdala projecting neurons is necessary and sufficient for taste valence representation
Conditioned taste aversion (CTA) is an associative learning paradigm, wherein consumption
of an appetitive tastant (eg, saccharin) is paired to the administration of a malaise-inducing …
of an appetitive tastant (eg, saccharin) is paired to the administration of a malaise-inducing …
Calcium/calmodulin-dependent protein kinase II and eukaryotic elongation factor 2 kinase pathways mediate the antidepressant action of ketamine
C Adaikkan, E Taha, I Barrera, O David… - Biological psychiatry, 2018 - Elsevier
Background Ketamine is an N-methyl-D-aspartate receptor antagonist, which on
administration produces fast-acting antidepressant responses in patients with major …
administration produces fast-acting antidepressant responses in patients with major …
Local memory allocation recruits memory ensembles across brain regions
Memories are thought to be stored in ensembles of neurons across multiple brain regions.
However, whether and how these ensembles are coordinated at the time of learning …
However, whether and how these ensembles are coordinated at the time of learning …
ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion
WG Li, MG Liu, S Deng, YM Liu, L Shang, J Ding… - Nature …, 2016 - nature.com
Acid-sensing ion channel 1a (ASIC1a) has been shown to play important roles in synaptic
plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term …
plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term …
[HTML][HTML] Parvalbumin interneuron inhibition onto anterior insula neurons projecting to the basolateral amygdala drives aversive taste memory retrieval
Memory retrieval refers to the fundamental ability of organisms to make use of acquired,
sometimes inconsistent, information about the world. Although memory acquisition has been …
sometimes inconsistent, information about the world. Although memory acquisition has been …
eEF2/eEF2K pathway in the mature dentate gyrus determines neurogenesis level and cognition
Levels of adult neurogenesis in the dentate gyrus (DG) of the hippocampus are correlated
with unique cognitive functions. However, the molecular pathways controlling it are poorly …
with unique cognitive functions. However, the molecular pathways controlling it are poorly …