The molecular memory code and synaptic plasticity: A synthesis

SJ Gershman - Biosystems, 2023 - Elsevier
The most widely accepted view of memory in the brain holds that synapses are the storage
sites of memory, and that memories are formed through associative modification of …

The insula and taste learning

A Yiannakas, K Rosenblum - Frontiers in Molecular Neuroscience, 2017 - frontiersin.org
The sense of taste is a key component of the sensory machinery, enabling the evaluation of
both the safety as well as forming associations regarding the nutritional value of ingestible …

The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice

Y Wu, C Chen, M Chen, K Qian, X Lv, H Wang… - Nature …, 2020 - nature.com
Reduced food intake is common to many pathological conditions, such as infection and toxin
exposure. However, cortical circuits that mediate feeding responses to these threats are less …

Learning depends on the information conveyed by temporal relationships between events and is reflected in the dopamine response to cues

PD Balsam, EH Simpson, K Taylor, A Kalmbach… - Science …, 2024 - science.org
Contemporary theories guiding the search for neural mechanisms of learning and memory
assume that associative learning results from the temporal pairing of cues and reinforcers …

Activity of insula to basolateral amygdala projecting neurons is necessary and sufficient for taste valence representation

H Kayyal, A Yiannakas, SK Chandran… - Journal of …, 2019 - jneurosci.org
Conditioned taste aversion (CTA) is an associative learning paradigm, wherein consumption
of an appetitive tastant (eg, saccharin) is paired to the administration of a malaise-inducing …

Calcium/calmodulin-dependent protein kinase II and eukaryotic elongation factor 2 kinase pathways mediate the antidepressant action of ketamine

C Adaikkan, E Taha, I Barrera, O David… - Biological psychiatry, 2018 - Elsevier
Background Ketamine is an N-methyl-D-aspartate receptor antagonist, which on
administration produces fast-acting antidepressant responses in patients with major …

Local memory allocation recruits memory ensembles across brain regions

A Lavi, M Sehgal, AF de Sousa, D Ter-Mkrtchyan… - Neuron, 2023 - cell.com
Memories are thought to be stored in ensembles of neurons across multiple brain regions.
However, whether and how these ensembles are coordinated at the time of learning …

ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion

WG Li, MG Liu, S Deng, YM Liu, L Shang, J Ding… - Nature …, 2016 - nature.com
Acid-sensing ion channel 1a (ASIC1a) has been shown to play important roles in synaptic
plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term …

[HTML][HTML] Parvalbumin interneuron inhibition onto anterior insula neurons projecting to the basolateral amygdala drives aversive taste memory retrieval

A Yiannakas, SK Chandran, H Kayyal, N Gould… - Current Biology, 2021 - cell.com
Memory retrieval refers to the fundamental ability of organisms to make use of acquired,
sometimes inconsistent, information about the world. Although memory acquisition has been …

eEF2/eEF2K pathway in the mature dentate gyrus determines neurogenesis level and cognition

E Taha, S Patil, I Barrera, J Panov, M Khamaisy… - Current Biology, 2020 - cell.com
Levels of adult neurogenesis in the dentate gyrus (DG) of the hippocampus are correlated
with unique cognitive functions. However, the molecular pathways controlling it are poorly …