Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …

Cuproptosis was a copper-dependent and unique kind of cell death that was separate from
existing other forms of cell death. The last decade has witnessed a considerable increase in …

Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Cuproptosis is a new cell death that depends on copper (Cu) ionophores to transport Cu into
cancer cells, which induces cell death. However, existing Cu ionophores are small …

Copper and other trace metals are essential for life. However, it is important that these
metals are present at the right amount in cells. Too little metal can impair the function of …

Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Cuproptosis, a newly identified form of regulated cell death that is copper‐dependent, offers
great opportunities for exploring the use of copper‐based nanomaterials inducing …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …