Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due
to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK …

Despite the improvement in clinical outcomes derived by the introduction of epidermal
growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of …

The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

EGF receptor (EGFR)–mutant lung cancers eventually become resistant to treatment with
EGFR tyrosine kinase inhibitors (TKI). The combination of EGFR-TKI afatinib and anti-EGFR …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …