Highlights•A comprehensive compilation and analysis of FDA approved and under clinical
trials peptide-based therapeutics.•Clinical trial peptides pipeline analysis reveals emerging …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules
which have antimicrobial activity and potent structure stability. We previously published the …

Cysteine conjugation is an important tool in protein research and relies on fast, mild and
chemoselective reactions. Cysteinyl thiols can either be modified with prefunctionalized …

Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …

Increasing disease-related proteins have been identified as novel therapeutic targets.
Macrocycles are emerging as potential solutions, bridging the gap between conventional …

Ribosome-dependent protein biosynthesis is an essential cellular process mediated by
transfer RNAs (tRNAs). Generally, ribosomally synthesized proteins are limited to the 22 …

The amidated peptides are an important class of biologically active compounds due to their
unique biological properties and wide applications as potential peptide drugs and …

Peptide stapling is recognized as an effective strategy for improving the proteolytic stability
and cell permeability of peptides. In this study, we present a novel approach for the site …

Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by
enabling and regulating the function of individual proteins. Thus, PPIs represent high-value …