Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

The peripheral nervous and immune systems are traditionally thought of as serving separate
functions. The line between them is, however, becoming increasingly blurred by new …

Gram-negative bacterial infections are accompanied by inflammation and somatic or
visceral pain. These symptoms are generally attributed to sensitization of nociceptors by …