Ecology, evolution and spillover of coronaviruses from bats

M Ruiz-Aravena, C McKee, A Gamble, T Lunn… - Nature Reviews …, 2022 - nature.com
In the past two decades, three coronaviruses with ancestral origins in bats have emerged
and caused widespread outbreaks in humans, including severe acute respiratory syndrome …

[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …

W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …

[HTML][HTML] SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract

YJ Hou, K Okuda, CE Edwards, DR Martinez… - Cell, 2020 - cell.com
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …

Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …

Structural and functional basis of SARS-CoV-2 entry by using human ACE2

Q Wang, Y Zhang, L Wu, S Niu, C Song, Z Zhang, G Lu… - Cell, 2020 - cell.com
The recent emergence of a novel coronavirus (SARS-CoV-2) in China has caused
significant public health concerns. Recently, ACE2 was reported as an entry receptor for …

Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe

V Thakur, S Bhola, P Thakur, SKS Patel, S Kulshrestha… - Infection, 2022 - Springer
The coronavirus disease-19 has left a permanent mark on the history of the human race.
Severe acute respiratory syndrome coronavirus-2 is a positive-sense single-stranded RNA …

A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells

M Hoffmann, H Kleine-Weber, S Pöhlmann - Molecular cell, 2020 - cell.com
The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike
protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2 cleavage site …

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

M Letko, A Marzi, V Munster - Nature microbiology, 2020 - nature.com
Over the past 20 years, several coronaviruses have crossed the species barrier into
humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS-CoV …

The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

M Hoffmann, H Kleine-Weber, N Krüger, M Müller… - BioRxiv, 2020 - biorxiv.org
The emergence of a novel, highly pathogenic coronavirus, 2019-nCoV, in China, and its
rapid national and international spread pose a global health emergency. Coronaviruses use …