Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont

AV Klimovich, TCG Bosch - BioEssays, 2018 - Wiley Online Library
Here we evaluate our current understanding of the function of the nervous system in Hydra,
a non‐bilaterian animal which is among the first metazoans that contain neurons. We …

Microbiota–host interactions shape ageing dynamics

M Popkes, DR Valenzano - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Occupying the interface between host and environment, host-associated microbes play
fundamental roles in nutrient absorption, essential metabolite synthesis, development of the …

Natural genetic variation drives microbiome selection in the Caenorhabditis elegans gut

F Zhang, JL Weckhorst, A Assié, C Hosea, CA Ayoub… - Current Biology, 2021 - cell.com
Host genetic landscapes can shape microbiome assembly in the animal gut by contributing
to the establishment of distinct physiological environments. However, the genetic …

Novel technologies uncover novel 'anti'-microbial peptides in Hydra sha** the species-specific microbiome

A Klimovich, TCG Bosch - Philosophical Transactions of …, 2024 - royalsocietypublishing.org
The freshwater polyp Hydra uses an elaborate innate immune machinery to maintain its
specific microbiome. Major components of this toolkit are conserved Toll-like receptor (TLR) …

Novel ADNP syndrome mice reveal dramatic sex-specific peripheral gene expression with brain synaptic and tau pathologies

G Karmon, S Sragovich, G Hacohen-Kleiman… - Biological …, 2022 - Elsevier
Background ADNP is essential for embryonic development. As such, de novo ADNP
mutations lead to an intractable autism/intellectual disability syndrome requiring …

Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra

K Rathje, B Mortzfeld, MP Hoeppner… - PLoS …, 2020 - journals.plos.org
The extent to which disturbances in the resident microbiota can compromise an animal's
health is poorly understood. Hydra is one of the evolutionary oldest animals with naturally …

Transgenesis in Hydra to characterize gene function and visualize cell behavior

A Klimovich, J Wittlieb, TCG Bosch - Nature protocols, 2019 - nature.com
The freshwater polyp Hydra is a cnidarian used as a model organism in a number of fields,
including the study of the origin and evolution of developmental mechanisms, aging …

The microbiome mediates environmental effects on aging

BB Finlay, S Pettersson, MK Melby, TCG Bosch - BioEssays, 2019 - Wiley Online Library
Humans' indigenous microbes strongly influence organ functions in an age‐and diet‐
dependent manner, adding an important dimension to aging biology that remains poorly …

Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization

J Bathia, K Schröder, S Fraune, T Lachnit… - Frontiers in …, 2022 - frontiersin.org
The freshwater polyp Hydra viridissima (H. viridissima) harbors endosymbiotic Chlorella
algae in addition to a species-specific microbiome. The molecular basis of the symbiosis …

Coral–microbe interactions: their importance to reef function and survival

C Tran - Emerging Topics in Life Sciences, 2022 - portlandpress.com
Many different microorganisms associate with the coral host in a single entity known as the
holobiont, and their interactions with the host contribute to coral health, thereby making them …