The metabolic serine hydrolases and their functions in mammalian physiology and disease
Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …
of an active site serine that is used for the hydrolysis of substrates. The membership of this …
Control of mitochondrial β-oxidation flux
S Eaton - Progress in lipid research, 2002 - Elsevier
The control of mitochondrial β-oxidation, including the delivery of acyl moieties from the
plasma membrane to the mitochondrion, is reviewed. Control of β-oxidation flux appears to …
plasma membrane to the mitochondrion, is reviewed. Control of β-oxidation flux appears to …
Deactivating fatty acids: acyl-CoA thioesterase-mediated control of lipid metabolism
V Tillander, SEH Alexson, DE Cohen - Trends in Endocrinology & …, 2017 - cell.com
The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A
(CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into …
(CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into …
The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism
MC Hunt, SEH Alexson - Progress in lipid research, 2002 - Elsevier
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to
the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular …
the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular …
Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis
J Himms-Hagen, ME Harper - Experimental Biology and …, 2001 - journals.sagepub.com
This hypothesis proposes a physiological role for uncoupling protein-3 (UCP3) in the export
of fatty acid anions from muscle and brown adipose tissue (BAT) mitochondria when fatty …
of fatty acid anions from muscle and brown adipose tissue (BAT) mitochondria when fatty …
Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling
Reactive oxygen species (ROS) produced by the mitochondrial respiratory chain can be a
redox signal, but whether they affect mitochondrial function is unclear. Here we show that …
redox signal, but whether they affect mitochondrial function is unclear. Here we show that …
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA
SA Novgorodov, BX Wu, TI Gudz, J Bielawski… - Journal of Biological …, 2011 - ASBMB
Reports suggest that excessive ceramide accumulation in mitochondria is required to initiate
the intrinsic apoptotic pathway and subsequent cell death, but how ceramide accumulates is …
the intrinsic apoptotic pathway and subsequent cell death, but how ceramide accumulates is …
Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?
The discovery of the human homologue of the thermogenic protein UCP1, named
uncoupling protein 3 (UCP3), boosted research on the role of this skeletal muscle protein in …
uncoupling protein 3 (UCP3), boosted research on the role of this skeletal muscle protein in …
The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes
MAK Westin, MC Hunt, SEH Alexson - Journal of Biological Chemistry, 2005 - ASBMB
Dicarboxylic acids are formed by ω-oxidation of fatty acids in the endoplasmic reticulum and
degraded as the CoA ester via β-oxidation in peroxisomes. Both synthesis and degradation …
degraded as the CoA ester via β-oxidation in peroxisomes. Both synthesis and degradation …
Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export
Uncoupling protein-3 (UCP3) is a mitochondrial inner membrane protein expressed most
abundantly in skeletal muscle and to a lesser extent in heart and brown adipose tissue …
abundantly in skeletal muscle and to a lesser extent in heart and brown adipose tissue …