Metabolic pathways are a central paradigm in biology. Historically, they have been defined
on the basis of their step-by-step discovery. However, the genome-scale metabolic networks …

INTRODUCTION Chemometrics is the discipline concerned with the ap-plication of statistical
and mathematical methods, as well as those methods based on mathematical logic, to …

Amyloid-β (Aβ) is present in humans as a 39-to 42-amino acid residue metabolic product of
the amyloid precursor protein. Although the two predominant forms, Aβ (1–40) and Aβ (1 …

The automated assignment of NOESY cross peaks has become a fundamental technique for
NMR protein structure analysis. A widely used algorithm for this purpose is implemented in …

The NMRPipe system is a UNIX software environment of processing, graphics, and analysis
tools designed to meet current routine and research-oriented multidimensional processing …

The new program Dyana (DYnamics Algorithm for Nmr Applications) for efficient calculation
of three-dimensional protein and nucleic acid structures from distance constraints and …

The NMR structures of the recombinant human prion protein, hPrP (23–230), and two C-
terminal fragments, hPrP (90–230) and hPrP (121–230), include a globular domain …

A new program package, XEASY, was written for interactive computer support of the
analysis of NMR spectra for three-dimensional structure determination of biological …

The NMR assignment of 13C, 15N-labeled proteins with the use of triple resonance
experiments is limited to molecular weights below∼ 25,000 Daltons, mainly because of low …

The recombinant murine prion protein, mPrP (23–231), was expressed in E. coli with uniform
15N-labeling. NMR experiments showed that the previously determined globular three …