Advances and utility of the human plasma proteome

EW Deutsch, GS Omenn, Z Sun, M Maes… - Journal of proteome …, 2021 - ACS Publications
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

[HTML][HTML] COVIDomics: The proteomic and metabolomic signatures of COVID-19

M Costanzo, M Caterino, R Fedele, A Cevenini… - International journal of …, 2022 - mdpi.com
Omics-based technologies have been largely adopted during this unprecedented global
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …

Evidence of structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients

T Thomas, D Stefanoni, M Dzieciatkowska… - Journal of proteome …, 2020 - ACS Publications
The SARS-CoV-2 beta coronavirus is the etiological driver of COVID-19 disease, which is
primarily characterized by shortness of breath, persistent dry cough, and fever. Because they …

Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution

E Caronna, A Ballvé, A Llauradó, VJ Gallardo… - …, 2020 - journals.sagepub.com
Objective To define headache characteristics and evolution in relation to COVID-19 and its
inflammatory response. Methods This is a prospective study, comparing clinical data and …

A time-resolved proteomic and prognostic map of COVID-19

V Demichev, P Tober-Lau, O Lemke, T Nazarenko… - Cell systems, 2021 - cell.com
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection
to severe organ damage and death. We characterized the time-dependent progression of …

Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

FX Danlos, C Grajeda-Iglesias, S Durand… - Cell Death & …, 2021 - nature.com
The circulating metabolome provides a snapshot of the physiological state of the organism
responding to pathogenic challenges. Here we report alterations in the plasma metabolome …

Circulating exosomes are strongly involved in SARS-CoV-2 infection

E Barberis, VV Vanella, M Falasca… - Frontiers in molecular …, 2021 - frontiersin.org
Knowledge of the host response to the novel coronavirus SARS-CoV-2 remains limited,
hindering the understanding of COVID-19 pathogenesis and the development of therapeutic …

Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes

A Viode, KK Smolen, P van Zalm, D Stevenson… - Science …, 2024 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by highly heterogeneous manifestations ranging from asymptomatic cases to death for still …

Specialized interferon action in COVID-19

MD Galbraith, KT Kinning, KD Sullivan, P Araya… - Proceedings of the …, 2022 - pnas.org
The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both
protective and harmful effects being documented. We report here a multiomics investigation …

High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion

PE Geyer, FM Arend, S Doll, ML Louiset… - EMBO Molecular …, 2021 - embopress.org
A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …