Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction
Troponin is a heterotrimeric Ca2+-binding protein that has a well-established role in
regulating striated muscle contraction. However, mounting evidence points to novel cellular …
regulating striated muscle contraction. However, mounting evidence points to novel cellular …
Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility
Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …
Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes
Introduction Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium
and triggering myofilament contraction. TNN variants are associated with development of …
and triggering myofilament contraction. TNN variants are associated with development of …
De novo Asp219Val mutation in cardiac tropomyosin associated with hypertrophic cardiomyopathy
AK Tsaturyan, EV Zaklyazminskaya, ME Polyak… - International Journal of …, 2022 - mdpi.com
Hypertrophic cardiomyopathy (HCM), caused by mutations in thin filament proteins,
manifests as moderate cardiac hypertrophy and is associated with sudden cardiac death …
manifests as moderate cardiac hypertrophy and is associated with sudden cardiac death …
[HTML][HTML] Novel Mutation Lys30Glu in the TPM1 Gene Leads to Pediatric Left Ventricular Non-Compaction and Dilated Cardiomyopathy via Impairment of Structural …
EV Zaklyazminskaya, VV Nefedova… - International Journal of …, 2024 - mdpi.com
Pediatric dilated cardiomyopathy (DCM) is a rare heart muscle disorder leading to the
enlargement of all chambers and systolic dysfunction. We identified a novel de novo variant …
enlargement of all chambers and systolic dysfunction. We identified a novel de novo variant …
Troponin I mutations R146G and R21C alter cardiac troponin function, contractile properties, and modulation by protein kinase A (PKA)-mediated phosphorylation
Two hypertrophic cardiomyopathy-associated cardiac troponin I (cTnI) mutations, R146G
and R21C, are located in different regions of cTnI, the inhibitory peptide and the cardiac …
and R21C, are located in different regions of cTnI, the inhibitory peptide and the cardiac …
The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation
Aberrant regulation of myocardial force production represents an early biomechanical defect
associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly …
associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly …
Cardiac troponin and tropomyosin: structural and cellular perspectives to unveil the hypertrophic cardiomyopathy phenotype
Inherited myopathies affect both skeletal and cardiac muscle and are commonly associated
with genetic dysfunctions, leading to the production of anomalous proteins. In …
with genetic dysfunctions, leading to the production of anomalous proteins. In …
Enhancing Chemotherapy Efficacy via an Autologous Erythrocyte-Anchoring Strategy with a Closed-System Drug-Transfer Device
L Feng, X Wang, Z Gao, Y Tong, X Yuan… - ACS Biomaterials …, 2024 - ACS Publications
Chemotherapeutic drugs often fail to localize efficiently to tumors when administered
intravenously, causing off-target effects. This study proposes an autologous erythrocyte (ER) …
intravenously, causing off-target effects. This study proposes an autologous erythrocyte (ER) …
Cooperativity of myosin interaction with thin filaments is enhanced by stabilizing substitutions in tropomyosin
DV Shchepkin, SR Nabiev, GV Kopylova… - Journal of Muscle …, 2017 - Springer
Muscle contraction is powered by myosin interaction with actin-based thin filaments
containing Ca 2+-regulatory proteins, tropomyosin and troponin. Coiled-coil tropomyosin …
containing Ca 2+-regulatory proteins, tropomyosin and troponin. Coiled-coil tropomyosin …