The discovery that lymphocyte subpopulations participate in distinct components of the
immune response focused attention onto the origins and function of lymphocytes more than …

Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of
ordered gene rearrangements which must be successfully performed if the cell is to survive …

The separate development of functionally intertwined lineages of lymphocytes known as B
cells and T cells is now recognized as a fundamental organizing principle of the adaptive …

The RAG-1 (recombination activating gene-l) genomic locus, which activates V (O) J
recombination when introduced into NIH 3T3 fibroblasts, was isolated by serial genomic …

Abstract The RAG1/RAG2 endonuclease (RAG) initiates the V (D) J recombination reaction
that assembles immunoglobulin heavy (IgH) and light (IgL) chain variable region exons from …

The mRNA isolated from B lymphocyte tumor cell lines directs synthesis of two forms of p
heavy chain, one with a molecular weight of 67K and one of 64K. When these cell lines are …

Transgenic mice bearing a c-myc oncogene subjugated to the lymphoid-specific
immunoglobulln heavy chain enhancer (Eu) develop clonal B lymphoid malignancies, but …

Two novel early B lymphocyte precursor populations have been identified by their capacity
to differentiate in Whitlock-Wltte bone marrow cultures. Cells expressing neither the B …

An amino acid sequence analysis of the N-terminal immunoglobulin heavy and light chain
variable regions (VH and VL) from 16 hybridoma proteins which bind phosphorylcholine as …

Immunofluorescent techniques were used to examine several aspects of B cell ontogeny in
humans. Large lymphoid cells containing intracytoplasmic IgM (pre‐B cells) were present in …